Lens-based wavefront sensorless adaptive optics swept source OCT

• Published in: Scientific reports Vol. 6; no. 1; p. 27620
• Main Authors: Jian, Yifan, Lee, Sujin, Ju, Myeong Jin, Heisler, Morgan, Ding, Weiguang, Zawadzki, Robert J., Bonora, Stefano, Sarunic, Marinko V.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.06.2016; Nature Publishing Group
• Subjects: 639/624/1107/510; 639/624/1111/55; Algorithms; Biomarkers - metabolism; Humanities and Social Sciences; Humans; Image Processing, Computer-Assisted; Lenses; Light; Light sources; multidisciplinary; Ophthalmology; Optical Devices; Optics; Optics and Photonics; Phenotype; Photoreceptors; Retina; Retina - physiology; Retinal Cone Photoreceptor Cells - metabolism; Science; Tomography; Tomography, Optical Coherence - methods; Uranus
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep27620

Optical coherence tomography (OCT) has revolutionized modern ophthalmology, providing depth resolved images of the retinal layers in a system that is suited to a clinical environment. Although the axial resolution of OCT system, which is a function of the light source bandwidth, is sufficient to resolve retinal features at a micrometer scale, the lateral resolution is dependent on the delivery optics and is limited by ocular aberrations. Through the combination of wavefront sensorless adaptive optics and the use of dual deformable transmissive optical elements, we present a compact lens-based OCT system at an imaging wavelength of 1060 nm for high resolution retinal imaging. We utilized a commercially available variable focal length lens to correct for a wide range of defocus commonly found in patient’s eyes and a novel multi-actuator adaptive lens for aberration correction to achieve near diffraction limited imaging performance at the retina. With a parallel processing computational platform, high resolution cross-sectional and en face retinal image acquisition and display was performed in real time. In order to demonstrate the system functionality and clinical utility, we present images of the photoreceptor cone mosaic and other retinal layers acquired in vivo from research subjects.