Association between resistin gene −420 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis

• Published in: Acta diabetologica Vol. 50; no. 2; pp. 267 - 272
• Main Authors: Wen, Ying, Lu, Peng, Dai, Ling
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.04.2013; Springer Nature B.V
• Subjects: Diabetes; Diabetes Mellitus, Type 2 - genetics; Gene Frequency; Genetic Predisposition to Disease - genetics; Genetics; Humans; Internal Medicine; Medicine; Medicine & Public Health; MEDLINE; Meta-analysis; Metabolic Diseases; Polymorphism; Polymorphism, Single Nucleotide - genetics; Resistin - genetics; Risk factors; Short Communication; Type 2 diabetes mellitus; Meta-analysis; Polymorphism; Resistin
• ISSN: 0940-5429; 1432-5233
• DOI: 10.1007/s00592-010-0247-8

Epidemiological studies on the association between the single nucleotide polymorphism (SNP) at −420 C/G (rs1862513) in the human resistin gene (RETN) and the risk of type 2 diabetes mellitus (T2DM) are conflicting. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Twelve studies with 5,935 cases and 5,959 controls were enrolled by searching the databases of Medline, EMBASE, and Cochrane. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. The heterogeneity and publication bias were investigated. The main analysis indicated no significant association [for allelic model: OR = 0.97 (0.92–1.03); for additive model: OR = 0.95 (0.83–1.09); for recessive model: OR = 0.98 (0.86–1.12); for dominant model: OR = 0.95 (0.88–1.04)]. Overall, no significant heterogeneity was found. Subgroup analysis by race and source of controls indicated no significant association. In conclusion, the current meta-analysis did not observe any association between the polymorphism of RETN −420 C/G and the risk of T2DM. The study may help us further understand the genetics of T2DM. However, larger and prospective studies are warranted to confirm this finding.