PHARMACOKINETICS OF ALFENTANIL DURING AND AFTER A FIXED RATE INFUSION

Twenty-nine patients (age range 14–81 yr) undergoing orthopaedic surgery received alfentanil 100 μg kg−1 given as two i.v. boluses followed by a fixed rate infusion of 1 μg kg−1 min−1 for 44–445 min. Additional 1-mg bolus doses of alfentanil were administered as required. Plasma samples were assayed...

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Published inBritish journal of anaesthesia : BJA Vol. 62; no. 6; pp. 610 - 615
Main Authors BEEM, H. VAN, PEER, A. VAN, GASPARINI, R., WOESTENBORGHS, R., HEYKANTS, J., NOORDUIN, H., EGMOND, J. VAN, CRUL, J.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.06.1989
Oxford University Press
Subjects
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Alfentanil
Anesthetics - administration & dosage
Anesthetics - pharmacokinetics
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Body Weight
Female
Fentanyl - administration & dosage
Fentanyl - analogs & derivatives
Fentanyl - pharmacokinetics
Humans
Infusions, Intravenous
Male
Medical sciences
Middle Aged
Neuropharmacology
Orthopedics
Pharmacology. Drug treatments
Time Factors
Human
General anesthesia
Analgesic
Pharmacokinetics
Perfusion
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Summary:Twenty-nine patients (age range 14–81 yr) undergoing orthopaedic surgery received alfentanil 100 μg kg−1 given as two i.v. boluses followed by a fixed rate infusion of 1 μg kg−1 min−1 for 44–445 min. Additional 1-mg bolus doses of alfentanil were administered as required. Plasma samples were assayed for alfentanil using radio-immunoassay. Pharmacokinetic parameters were estimated by a model-independent approach and by curve-fitting. Regression analysis showed no statistical relationship between T, CI or Vd and the duration of the infusion, total dose or body weight. We found no significant correlation between age and T of alfentanil for patients younger than 40 yr. For patients older than 40 yr, T increased linearly with age. There was no significant decrease in Cl with age, although the lower values for CI (100–200 ml min−1) were generally found in subjects older than 60 yr. The present study demonstrated that a 100-μg kg−1 loading dose and a 1-μg kg−1 min−1 infusion may be appropriate for analgesia in general surgical procedures.
Bibliography:istex:AACEFB27346DB480BCC3C96F2E769311379BBE6B
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ArticleID:62.6.610
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/62.6.610