Management and Outcomes of Neonatal Arteriovenous Brain Malformations with Cardiac Failure: A 17 Years' Experience in a Tertiary Referral Center

• Published in: The Journal of pediatrics Vol. 218; pp. 85 - 91.e2
• Main Authors: Giorgi, Laetitia, Durand, Phillippe, Morin, Luc, Miatello, Jordi, Merchaoui, Zied, Lambert, Virginie, Boithias, Claire, Senat, Marie Victoire, Stos, Bertrand, Maurey, Hélène, Adamsbaum, Catherine, Tissières, Pierre, Saliou, Guillaume, Spelle, Laurent, Ozanne, Augustin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2020; Elsevier
• Subjects: dural venous fistulae; embolization; encephalomalacia; Human health and pathology; Life Sciences; neurologic outcome; newborn; persistent pulmonary hypertension of the newborn; pial fistulae; right cardiac failure; vein of galen aneurysmal malformation; SVC; neurologic outcome; embolization; MRI; pial fistulae; persistent pulmonary hypertension of the newborn; NICU; newborn; VGAM; dural venous fistulae; encephalomalacia; VGAD; vein of galen aneurysmal malformation; right cardiac failure
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2019.10.090

To assess the management and outcomes of neonatal arteriovenous brain malformations (mostly vein of Galen malformations) complicated by cardiac failure in the era of prenatal diagnosis and endovascular treatment in a tertiary referral center. This observational study included 77 living newborn infants with arteriovenous brain malformations with cardiac failure, admitted to our referral center from 2001 to 2017. All infants underwent cardiovascular evaluation including echocardiogram and brain magnetic resonance imaging. Long-term survivors had standard neurocognitive assessments. Infants were admitted to the neonatal intensive care unit at a median of 5 days of age (including 18 inborn patients since 2009). Sixty transarterial shunt embolizations were performed in 46 patients during their first month (at a median age of 7.5 days) or postponed beyond the first month in another 10 long-term survivors. Embolization was not performed in 21 infants, including 19 nonsurvivors with severe brain injury, uncontrolled cardiac failure, or multiple organ failure. Cardiac failure requiring vasopressor infusion occurred in 48 patients (64%) during the hospitalization. Infants who survived the first month underwent a median of 3 embolization sessions. Among the 51 survivors, 21 had a good outcome and 19 had a poor outcome at follow-up (median age, 5.3 years); 11 children were lost to follow-up. In the era of multidisciplinary prenatal diagnosis, using a standardized care protocol, 47% of liveborn infants with an arteriovenous shunt malformation with cardiac failure experienced a favorable outcome.