Acute Kidney Injury after Using Contrast during Cardiac Catheterization in Children with Heart Disease

• Published in: Journal of Korean medical science Vol. 29; no. 8; pp. 1102 - 1107
• Main Authors: Hwang, Young Ju, Hyun, Myung Chul, Choi, Bong Seok, Chun, So Young, Cho, Min Hyun
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.08.2014; 대한의학회
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - chemically induced; Acute Kidney Injury - urine; Biomarkers - urine; Cardiac Catheterization - adverse effects; Child; Contrast Media - adverse effects; Fatty Acid-Binding Proteins - urine; Female; Heart Defects, Congenital - complications; Heart Defects, Congenital - diagnostic imaging; Humans; Iohexol - adverse effects; Iohexol - analogs & derivatives; Male; Original; Radiography, Interventional - adverse effects; Reproducibility of Results; Sensitivity and Specificity; 의학일반; Kidney Injury Molecule-1; Acute Kidney Injury; Liver-type Fatty Acid-Binding Protein; Contrast
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2014.29.8.1102

Acute kidney injury (AKI) is closely associated with the mortality of hospitalized patients and long-term development of chronic kidney disease, especially in children. The purpose of our study was to assess the evidence of contrast-induced AKI after cardiac catheterization in children with heart disease and evaluate the clinical usefulness of candidate biomarkers in AKI. A total of 26 children undergoing cardiac catheterization due to various heart diseases were selected and urine and blood samples were taken at 0 hr, 6 hr, 24 hr, and 48 hr after cardiac catheterization. Until 48 hr after cardiac catheterization, there was no significant increase in serum creatinine level in all patients. Unlike urine kidney injury molecule-1, IL-18 and neutrophil gelatinase-associated lipocalin, urine liver-type fatty acid-binding protein (L-FABP) level showed biphasic pattern and the significant difference in the levels of urine L-FABP between 24 and 48 hr. We suggest that urine L-FABP can be one of the useful biomarkers to detect subclinical AKI developed by the contrast before cardiac surgery.