Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer’s disease

• Published in: Molecular diversity Vol. 17; no. 3; pp. 515 - 524
• Main Authors: Cao, Ying Ying, Wang, Ling, Ge, Hu, Lu, Xi Lin, Pei, Zhong, Gu, Qiong, Xu, Jun
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.08.2013; Springer Nature B.V
• Subjects: Alzheimer Disease - drug therapy; Amyloid beta-Peptides - drug effects; Animals; Biochemistry; Biomedical and Life Sciences; Caenorhabditis elegans - drug effects; Caffeic Acids - pharmacology; Cell Line, Tumor; Circular Dichroism; Copper - chemistry; Drug Evaluation, Preclinical; Full-Length Paper; Humans; Iron - chemistry; Iron Chelating Agents; Lactates - pharmacology; Life Sciences; Molecular Dynamics Simulation; Organic Chemistry; Oxidative Stress - drug effects; Pharmacy; Plant Extracts - pharmacology; Plaque, Amyloid - drug therapy; Polymer Sciences; Reactive Oxygen Species - antagonists & inhibitors; Salvia miltiorrhiza; Serum Amyloid A Protein - drug effects; Serum Amyloid A Protein - metabolism; Zinc - chemistry; Amyloid; Neuroprotecitve; Alzheimer’s disease; Salvianolic acid A; Anti-oxidant
• ISSN: 1381-1991; 1573-501X
• DOI: 10.1007/s11030-013-9452-z

The effects of Salvianolic acid A (Sal A) on the treatment of Alzheimer’s disease (AD) were investigated. Sal A significantly inhibits amyloid beta ( A β ) self-aggregation and disaggregates pre-formed A β fibrils, reduces metal-induced A β aggregation through chelating metal ions, and blocks the formation of reactive oxygen species (ROS) in SH-SY5Y cells. Sal A protects cells against A β 42 -induced toxicity. Furthermore, Sal A, possibly because of the effects of decreasing toxicity effects of A β species, alleviates A β -induced paralysis in transgenic Caenorhabditis elegans . Circular dichroism (CD) experiments and Molecular dynamic (MD) simulations demonstrate that Sal A inhibits A β self-aggregation through binding to the C-terminus of A β , and therefore stabilizing the α -helical conformations. Altogether, our data show that Sal A, as the multifunctional agent, is likely to be promising therapeutics for AD.