Low levels of ventricular CSF orexin/hypocretin in advanced PD

The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonia...

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Bibliographic Details
Published inNeurology Vol. 61; no. 4; p. 540
Main Authors Drouot, X, Moutereau, S, Nguyen, J P, Lefaucheur, J P, Créange, A, Remy, P, Goldenberg, F, d'Ortho, M P
Format Journal Article
LanguageEnglish
Published United States 26.08.2003
Subjects
Antiparkinson Agents - therapeutic use
Arousal - physiology
Carrier Proteins - cerebrospinal fluid
Cerebral Ventricles
Combined Modality Therapy
Disorders of Excessive Somnolence - cerebrospinal fluid
Disorders of Excessive Somnolence - etiology
Electric Stimulation Therapy
Female
Humans
Intracellular Signaling Peptides and Proteins
Male
Neuropeptides - cerebrospinal fluid
Neuropeptides - deficiency
Orexins
Parkinson Disease - cerebrospinal fluid
Parkinson Disease - complications
Parkinson Disease - drug therapy
Parkinson Disease - therapy
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Summary:The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.
ISSN:1526-632X
DOI:10.1212/01.wnl.0000078194.53210.48