Successive pregnancies with delivery of two healthy infants in a couple who was discordant for human immunodeficiency virus infection

• Published in: Fertility and sterility Vol. 78; no. 2; pp. 421 - 423
• Main Authors: Peña, Joseph E, Klein, Jeff, Thornton, Melvin, Chang, Peter L, Sauer, Mark V
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2002; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Embryo Transfer; Female; Fundamental and applied biological sciences. Psychology; HIV; HIV Seronegativity; HIV Seropositivity; HIV-1; Humans; ICSI; IVF; Male; Middle Aged; Mother. Fetoplacental unit. Mammary gland. Milk; Pregnancy; Pregnancy Outcome; Pregnancy. Parturition. Lactation; reproduction; Sperm Injections, Intracytoplasmic; Vertebrates: reproduction; IVF; ICSI; HIV; pregnancy; reproduction; Virus; Case study; In vitro fertilization embryo transfer; Pregnancy; Human; Reproduction; Intracytoplasmic sperm injection; Assisted procreation; Retroviridae; Female; Human immunodeficiency virus; Lentivirus
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(02)03213-2

Objective: To describe two successive pregnancies resulting in two healthy infants in an HIV-discordant couple who underwent IVF-ICSI. Design: Case report. Setting: University-based infertility clinic. Patient(s): A couple seeking fertility treatment in which the male partner was seropositive for HIV-1. Intervention(s): Controlled ovarian hyperstimulation and IVF-ET with ICSI. Main Outcome Measure(s): Pregnancy outcome and HIV-1 seroconversion. Result(s): The couple delivered two healthy infants on successive pregnancies with use of IVF-ET with ICSI. Conclusion(s): For HIV-discordant couples in which the male partner is seropositive for HIV-1, IVF with ICSI is a viable option.