Trans-ethnic study confirmed independent associations of HLA-A02:06 and HLA-B44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

• Published in: Scientific reports Vol. 4; no. 1; p. 5981
• Main Authors: Ueta, Mayumi, Kannabiran, Chitra, Wakamatsu, Tais Hitomi, Kim, Mee Kum, Yoon, Kyung-Chul, Seo, Kyoung Yul, Joo, Choun-Ki, Sangwan, Virender, Rathi, Varsha, Basu, Sayan, Shamaila, Almas, Lee, Hyo Seok, Yoon, Sangchul, Sotozono, Chie, Gomes, José Álvaro Pereira, Tokunaga, Katsushi, Kinoshita, Shigeru
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.08.2014; Nature Publishing Group
• Subjects: 45; 692/308/2056; 692/499; Adolescent; Adult; Alleles; Anti-inflammatory agents; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Brazil; Child; Cold remedies; Dry Eye Syndromes - ethnology; Dry Eye Syndromes - etiology; Dry Eye Syndromes - genetics; Dry Eye Syndromes - immunology; Epithelium, Corneal - immunology; Epithelium, Corneal - pathology; Ethnic Groups; Female; Gene Frequency; Histocompatibility antigen HLA; HLA-A2 Antigen - genetics; HLA-A2 Antigen - immunology; HLA-B44 Antigen - genetics; HLA-B44 Antigen - immunology; Humanities and Social Sciences; Humans; India; Inflammation; Male; Middle Aged; Minority & ethnic groups; Mucosa; Multi-Ingredient Cold, Flu, and Allergy Medications - adverse effects; multidisciplinary; Nonsteroidal anti-inflammatory drugs; Republic of Korea; Retinal Pigment Epithelium - immunology; Retinal Pigment Epithelium - pathology; Risk Factors; Science; Science (multidisciplinary); Skin; Skin diseases; Stevens-Johnson syndrome; Stevens-Johnson Syndrome - ethnology; Stevens-Johnson Syndrome - etiology; Stevens-Johnson Syndrome - genetics; Stevens-Johnson Syndrome - immunology; Toxic epidermal necrolysis; Trichiasis - ethnology; Trichiasis - etiology; Trichiasis - genetics; Trichiasis - immunology; Brazil; Republic of Korea; India
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep05981

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian and Korean patients with CM-SJS/TEN with SOC and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06 . We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population and that HLA-A*02:06 might be weakly associated in the Korean- but not the Indian and Brazilian population.