Comparison Between Stereotactic and Conventional Radiotherapy for Solitary Lung Tumor After Resection of Lung Cancer

• Published in: Anticancer research Vol. 39; no. 6; pp. 2957 - 2962
• Main Authors: Takahashi, Shigeo, Go, Tetsuhiko, Anada, Masahide, Kinoshita, Toshifumi, Nishide, Takamasa, Yokomise, Hiroyasu, Shibata, Toru
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.06.2019
• Subjects: Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung - radiotherapy; Dose Fractionation, Radiation; Female; Humans; Lung cancer; Lung Neoplasms - radiotherapy; Male; Middle Aged; Non-small cell lung carcinoma; Radiation therapy; Radiosurgery - methods; Retrospective Studies; Survival Rate; Toxicity; Treatment Outcome; Tumors; salvage radiotherapy; second primary lung cancer; recurrent lung cancer; Stereotactic ablative radiotherapy
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.13426

We retrospectively compared stereotactic body radiotherapy (SBRT) with conventionally fractionated radiotherapy (CFRT) for a solitary lung tumor after resection of a non-small cell lung cancer (NSCLC), due to a lack of data concerning whether SBRT or CFRT is more effective in this setting. SBRT using 48 Gy in 4 fractions was administered to 15 patients with a peripheral tumor (SBRT group). CFRT using 66-70 Gy in 33-35 fractions was administered to 11 patients with a central tumor (CFRT group). The median follow-up time was 32 months (range: 9-79 months). The 3-year overall survival rates in SBRT and CFRT groups were 81% and 40%, respectively (p=0.008). The 3-year local control rates in SBRT and CFRT groups were 83% and 35%, respectively (p=0.035). Regarding toxicities, no significant differences were found between the two groups. Compared to CFRT, SBRT may be more effective in solitary-lung-tumor patients after the complete resection of an NSCLC as with inoperable-stage I-NSCLC patients.