Phosphorylcholine Coating of Bypass Systems Used for Young Infants Does Not Attenuate the Inflammatory Response

• Published in: The Annals of thoracic surgery Vol. 81; no. 4; pp. 1455 - 1459
• Main Authors: Draaisma, Anjo M., Hazekamp, Mark G., Anes, Nanning, Schoof, Paul H., Hack, C. Erik, Sturk, Augueste, Dion, Robert A.E.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2006; Elsevier Science
• Subjects: Biological and medical sciences; Cardiopulmonary Bypass - adverse effects; Cardiopulmonary Bypass - instrumentation; Complement Activation; Double-Blind Method; Equipment Design; Female; Humans; Infant; Inflammation - etiology; Inflammation - prevention & control; Male; Medical sciences; Phosphorylcholine; Prospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the respiratory system; Treatment Failure; 25; Human; Respiratory disease; Use; Infant; Inflammation; Thorax; Coatings; System; Response; Treatment; Bypass; Surgery; Coating
• ISSN: 0003-4975; 1552-6259
• DOI: 10.1016/j.athoracsur.2005.11.058

Contact of blood with the artificial surfaces of the cardiopulmonary bypass (CPB) system is considered to be a main cause of complement activation. Improving the biocompatibility of the system by reduction of contact activation of blood elements and thereby producing less inflammatory response is evidently desired, especially for neonates and infants who are more susceptible to the deleterious effects of CPB. A phosphorylcholine coating, Phisio, is designed to mimic the natural interfaces of blood. The aim of this study is to compare the influence of a phosphorylcholine-coated CPB system versus an uncoated CPB system on complement activation and clinical outcomes. In this prospective, randomized, blind, one-center study, 28 neonates and infants with a bodyweight between 3 and 6 kg who were undergoing cardiopulmonary bypass were divided in two groups, the phosphorylcholine group and the control group. Thirteen patients were assigned to the phosphorylcholine group and 15 patients to the control group. Patients with Down syndrome, prematurity, cyanosis, or reoperation were excluded. Complement factor C3b/c, human neutrophil elastase (HNE), interleukin-6, and C-reactive protein were measured before, during, and after CPB. Duration of intensive care stay, ventilation time, highest body temperature, and inotropic medication were the clinical variables. No significant differences were found between the groups for complement factor C3b/c, HNE, interleukin-6, or C-reactive protein during and after CPB. No clinical differences were observed between the groups. Phosphorylcholine coating does not attenuate the complement activation during CPB in neonates and infants.