Pericardial effusion and tamponade following interferon alpha treatment for locally advanced melanoma

Regional Metastatic Melanoma has a relatively high mortality rate. Adjuvant interferon-alpha (IFN-α) has been shown to improve disease-free survival, post-resection. Cardiotoxicity associated with IFN-α use has been described previously in the literature, but here we describe the first case of peric...

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Bibliographic Details
Published inMedical oncology (Northwood, London, England) Vol. 29; no. 2; pp. 1304 - 1307
Main Authors Rauw, Jennifer, Ahmed, Shaheeda, Petrella, Teresa
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.06.2012
Springer Nature B.V
Subjects
Acuity
Adjuvants
Adult
alpha -Interferon
Cardiac Tamponade - chemically induced
Case Report
Effusion
Female
Heart
Hematology
Humans
Interferon-alpha - adverse effects
Internal Medicine
Medicine
Medicine & Public Health
Melanoma
Melanoma - drug therapy
Melanoma - secondary
Metastases
Mortality
Oncology
Pathology
Pericardial Effusion - chemically induced
Prognosis
Recombinant Proteins - adverse effects
Survival
Tamponade
Melanoma [C04.557.665.510]
Pericardial effusion [C14.280.695]
Interferons [D12.776.467.374.440]
Skin neoplams [C04.588.805]
Cardiac tamponade [C14.280.155]
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Summary:Regional Metastatic Melanoma has a relatively high mortality rate. Adjuvant interferon-alpha (IFN-α) has been shown to improve disease-free survival, post-resection. Cardiotoxicity associated with IFN-α use has been described previously in the literature, but here we describe the first case of pericardial effusion with cardiac tamponade secondary to IFN-α 2b treatment of melanoma. Clinicians should be aware of this potentially lethal complication and the possible acuity of its onset.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-011-9935-7