Urinary excretion patterns of endogenously produced alcohols in type 1 (IDDM) and type 2 (NIDDM) diabetes mellitus compared with healthy control subjects

• Published in: Diabetes research and clinical practice Vol. 10; no. 2; pp. 161 - 165
• Main Authors: Krönert, Kornelia, Künzel, M., Reutter, B., Zimmermann, C., Liebich, H.M., Luft, D., Eggstein, M.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.10.1990; Elsevier Science
• Subjects: Adult; Alcohols - urine; Associated diseases and complications; Biological and medical sciences; Blood Glucose - analysis; Diabetes mellitus, type 1 (IDDM); Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - urine; Diabetes mellitus, type 2 (NIDDM); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - urine; Diabetes. Impaired glucose tolerance; Diabetic neuropathy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Gas-chromatography-mass spectrometry; Glycated Hemoglobin A - analysis; Humans; Male; Medical sciences; Middle Aged; Reference Values; Urinary alcohol excretion; Diabetic neuropathy; Diabetes mellitus, type 1 (IDDM); Diabetes mellitus, type 2 (NIDDM); Urinary alcohol excretion; Gas-chromatography-mass spectrometry; Endocrinopathy; Human; Urine; Excretion; Nervous system diseases; Pathogenesis; Insulin dependent diabetes; Alcohol; Complication; Endogenous substance; Neuropathy; Non insulin dependent diabetes
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/0168-8227(90)90039-V

Urinary excretion patterns of various endogenously produced alcohols, such as ethanol, propanol, isobutanol, butanol, and isopentanol, were evaluated in 17 type 1 (IDDM) and 15 type 2 (NIDDM) diabetic patients, and in two different groups of healthy control subjects ( n = 12, n = 8, respectively) matched for sex, age and weight. In addition to the urinary alcohol excretion determined by gas-chromatography and mass-spectrometry, four cardiovascular reflex tests were performed, and the motor and sensory conduction velocities of three different peripheral nerves were measured. In the type 1 diabetic patients, urinary excretions of ethanol and propanol were significantly higher than in the control subjects ( P < 0.0001, P < 0.00001, respectively), whereas the control subjects exhibited significantly higher urinary excretion rates of the other three alcohols ( P < 0.007, P < 0.002, respectively) compared with the type 1 diabetic patients. In the type 2 diabetic patients, only the urinary excretion of propanol was significantly elevated ( P < 0.002) compared with the control subjects, while the urinary excretion rates of butanol and isopentanol were significantly lower ( P < 0.02, P < 0.05, respectively) than in the controls. Urinary alcohol excretions were not related to diabetic peripheral neuropathy in both groups studied. The clinical meaning of the urinary excretion patterns of different endogenously produced alcohols in diabetes mellitus has to be further evaluated.