Maintenance of Epigenetic Information

The genome is subject to a diverse array of epigenetic modifications from DNA methylation to histone posttranslational changes. Many of these marks are somatically stable through cell division. This article focuses on our knowledge of the mechanisms governing the inheritance of epigenetic marks, par...

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Bibliographic Details
Published inCold Spring Harbor perspectives in biology Vol. 8; no. 5; p. a019372
Main Authors Almouzni, Geneviève, Cedar, Howard
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.05.2016
Subjects
CONCEPT
DNA Methylation
DNA Replication - physiology
Epigenesis, Genetic
Gene Expression Regulation
Histone Chaperones - physiology
Histone Code
Models, Genetic
Protein Processing, Post-Translational
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Summary:The genome is subject to a diverse array of epigenetic modifications from DNA methylation to histone posttranslational changes. Many of these marks are somatically stable through cell division. This article focuses on our knowledge of the mechanisms governing the inheritance of epigenetic marks, particularly, repressive ones, when the DNA and chromatin template are duplicated in S phase. This involves the action of histone chaperones, nucleosome-remodeling enzymes, histone and DNA methylation binding proteins, and chromatin-modifying enzymes. Last, the timing of DNA replication is discussed, including the question of whether this constitutes an epigenetic mark that facilitates the propagation of epigenetic marks.
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ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a019372