Andrographolide Suppresses IL-6/Stat3 Signaling in Peripheral Blood Mononuclear Cells from Patients with Chronic Rhinosinusitis with Nasal Polyps

• Published in: Inflammation Vol. 37; no. 5; pp. 1738 - 1743
• Main Authors: Kou, Wei, Sun, Rong, Wei, Ping, Yao, Hong-Bing, Zhang, Cheng, Tang, Xin-Ye, Hong, Su-Ling
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.10.2014; Springer Nature B.V
• Subjects: Adult; Andrographis paniculata; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Biomedical and Life Sciences; Biomedicine; Cells, Cultured; Chronic Disease; Diterpenes - pharmacology; Diterpenes - therapeutic use; Dose-Response Relationship, Drug; Female; Humans; Immunology; Interleukin-6 - antagonists & inhibitors; Interleukin-6 - metabolism; Internal Medicine; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; Male; Middle Aged; Nasal Polyps - drug therapy; Nasal Polyps - metabolism; Pathology; Pharmacology/Toxicology; Rheumatology; Rhinitis - drug therapy; Rhinitis - metabolism; Signal Transduction - drug effects; Signal Transduction - physiology; Sinusitis - drug therapy; Sinusitis - metabolism; STAT3 Transcription Factor - antagonists & inhibitors; STAT3 Transcription Factor - metabolism; Young Adult; chronic rhinosinusitis with nasal polyps; IL-6; Th17. VAS; IL-17; andrographolide
• ISSN: 0360-3997; 1573-2576; 1573-2576
• DOI: 10.1007/s10753-014-9902-5

The mechanisms underlying the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) remain largely unknown. CRSwNP has garnered considerable public health concern owing to its high incidence and unsatisfactory treatment outcomes. Herbal remedies are promising candidates for the treatment of CRSwNP. We examined the utility of andrographolide, a diterpenoid lactone extracted from the Chinese herb Andrographis paniculata , an anti-inflammatory agent for CRSwNP treatment by evaluating interleukin (IL)-6 and IL-17 production and monitoring T helper 17 (Th17) differentiation of peripheral blood mononuclear cells (PBMCs) isolated from 20 Chinese CRSwNP patients and 11 control subjects. All CRSwNP patients exhibited clinical features of CRSwNP. Andrographolide significantly inhibited IL-6 and IL-17 production, suppressed p-Stat3 expression, and inhibited Th17 differentiation of PBMCs in vitro . These findings suggested that andrographolide has useful anti-inflammatory properties and could be used for the treatment of CRSwNP.