Action, observation or imitation of virtual hand movement affect differently regions of the mirror neuron system and the default mode network

• Published in: Brain imaging and behavior Vol. 12; no. 5; pp. 1363 - 1378
• Main Authors: Brihmat, Nabila, Tarri, Mohamed, Quidé, Yann, Anglio, Ketty, Pavard, Bernard, Castel-Lacanal, Evelyne, Gasq, David, De Boissezon, Xavier, Marque, Philippe, Loubinoux, Isabelle
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2018; Springer Nature B.V
• Subjects: Adult; Biomedical and Life Sciences; Biomedicine; Brain; Brain - diagnostic imaging; Brain - physiology; Brain Mapping; Computer applications; Cortex (cingulate); Cortex (parietal); Cortex (premotor); Deactivation; Female; Functional magnetic resonance imaging; Hand; Humans; Imitative Behavior - physiology; Magnetic Resonance Imaging; Male; Mirror Neurons - physiology; Motion Perception - physiology; Motor Activity - physiology; Neural Pathways - diagnostic imaging; Neural Pathways - physiology; Neuropsychology; Neuroradiology; Neurosciences; Original Research; Oxygenation; Proof of Concept Study; Protocol (computers); Psychiatry; Psychomotor Performance - physiology; Rehabilitation; Resource management; Virtual Reality; Visual cortex; Visual pathways; Visual stimuli; Mirror Neuron System; Functional magnetic resonance imaging; Healthy Participants; Virtual Reality; Precuneus/posterior Cingulate Cortex complex; Imitation
• ISSN: 1931-7557; 1931-7565
• DOI: 10.1007/s11682-017-9804-x

Virtual reality (VR)-based paradigms use visual stimuli that can modulate visuo-motor networks leading to the stimulation of brain circuits. The aims of this study were to compare the changes in blood-oxygenation level dependent (BOLD) signal when watching and imitating moving real (RH) and virtual hands (VH) in 11 healthy participants (HP). No differences were found between the observation of RH or VH making this VR-based experiment a promising tool for rehabilitation protocols. VH-imitation involved more the ventral premotor cortex (vPMC) as part of the mirror neuron system (MNS) compared to execution and VH-observation conditions. The dorsal-anterior Precuneus (da-Pcu) as part of the Precuneus/posterior Cingulate Cortex (Pcu/pCC) complex, a key node of the Default Mode Network (DMN), was also less deactivated and therefore more involved. These results may reflect the dual visuo-motor roles for the vPMC and the implication of the da-Pcu in the reallocation of attentional and neural resources for bimodal task management. The ventral Pcu/pCC was deactivated regardless of the condition confirming its role in self-reference processes. Imitation of VH stimuli can then modulate the activation of specific areas including those belonging to the MNS and the DMN.