Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma
Primary retroperitoneal liposarcoma is generally regarded as a genetic disorder. We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes ( MDM2, CDK4, CDC27, FPGS, IGFN1 and PRAMEF13 ) in 138 patients and 131 healthy control subjects to evaluate the effects of...
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Published in | Scientific reports Vol. 5; no. 1; p. 9079 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
13.03.2015
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | Primary retroperitoneal liposarcoma is generally regarded as a genetic disorder. We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes (
MDM2, CDK4, CDC27, FPGS, IGFN1
and
PRAMEF13
) in 138 patients and 131 healthy control subjects to evaluate the effects of genetic factors on individual susceptibility to primary retroperitoneal liposarcoma in Chinese population. Three SNPs (rs2870820, rs1695147, rs3730536) of
MDM2
showed significant differences in single-loci genotypes and allele frequencies between case and control groups (
p
< 0.05). The minor allele G of SNP rs10760502 in
FPGS
(folylpolyglutamate synthase) gene was significantly associated with increased risk for primary retroperitoneal liposarcoma, compared with major allele A. Our data suggest that
FPGS
variant in Chinese population may affect individual susceptibility to primary retroperitoneal liposarcoma. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/srep09079 |