Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma

• Published in: Scientific reports Vol. 5; no. 1; p. 9079
• Main Authors: Miao, Chengli, Liu, Ding, Zhang, Feng, Wang, Youxin, Zhang, Yanbin, Yu, Junhui, Zhang, Zhanzhi, Liu, Gang, Li, Bing, Liu, Xing, Luo, Chenghua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.03.2015; Nature Publishing Group
• Subjects: 38; 45; 631/208/68; 631/67/1798; 82; Adult; Aged; Alleles; Amino Acid Sequence; Case-Control Studies; Computational Biology; Cyclin-dependent kinase 4; DNA Mutational Analysis; Female; Folylpolyglutamate synthase; Gastric cancer; Gene Frequency; Genetic Association Studies; Genetic disorders; Genetic factors; Genetic Predisposition to Disease; Genotype; Humanities and Social Sciences; Humans; Linkage Disequilibrium; Liposarcoma; Liposarcoma - genetics; Liposarcoma - pathology; Male; MDM2 protein; Middle Aged; Molecular Sequence Data; multidisciplinary; Mutation; Peptide Synthases - chemistry; Peptide Synthases - genetics; Polymorphism; Polymorphism, Single Nucleotide; Population genetics; Protein Structure, Secondary; Retroperitoneal Neoplasms - genetics; Retroperitoneal Neoplasms - pathology; Risk Factors; Science; Single-nucleotide polymorphism; Tumor Burden; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep09079

Primary retroperitoneal liposarcoma is generally regarded as a genetic disorder. We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes ( MDM2, CDK4, CDC27, FPGS, IGFN1 and PRAMEF13 ) in 138 patients and 131 healthy control subjects to evaluate the effects of genetic factors on individual susceptibility to primary retroperitoneal liposarcoma in Chinese population. Three SNPs (rs2870820, rs1695147, rs3730536) of MDM2 showed significant differences in single-loci genotypes and allele frequencies between case and control groups ( p < 0.05). The minor allele G of SNP rs10760502 in FPGS (folylpolyglutamate synthase) gene was significantly associated with increased risk for primary retroperitoneal liposarcoma, compared with major allele A. Our data suggest that FPGS variant in Chinese population may affect individual susceptibility to primary retroperitoneal liposarcoma.