Inhibition of influenza A virus hemagglutinin and induction of interferon by synthetic sialylated glycoconjugates

Multivalent forms of neoglycoproteins and polyacrylamides containing sialic acid were prepared and shown to be potent inhibitors of influenza A virus (H3N2) hemagglutinin with chick red blood cells. The synthetic sialylated glycoconjugates, although they were neuraminidase substrates, did not suppre...

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Bibliographic Details
Published inCanadian journal of microbiology Vol. 37; no. 3; p. 233
Main Authors Gamian, A, Chomik, M, Laferrière, C A, Roy, R
Format Journal Article
LanguageEnglish
Published Canada 01.03.1991
Subjects
Animals
Chick Embryo
Gene Expression Regulation - drug effects
Glycoconjugates - chemistry
Glycoconjugates - pharmacology
Hemagglutination, Viral - drug effects
Hemagglutinins, Viral - antagonists & inhibitors
Influenza A virus - drug effects
Influenza A virus - physiology
Interferons - biosynthesis
Mice
Mice, Inbred Strains
N-Acetylneuraminic Acid
Neuraminidase - metabolism
Sialic Acids - pharmacology
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Summary:Multivalent forms of neoglycoproteins and polyacrylamides containing sialic acid were prepared and shown to be potent inhibitors of influenza A virus (H3N2) hemagglutinin with chick red blood cells. The synthetic sialylated glycoconjugates, although they were neuraminidase substrates, did not suppress viral neuraminidase and did not reduce infectivities in chick embryos. The copolyacrylamide conjugate containing a spacer group of approximately 11 A (1 A = 0.1 nm) between the polymer backbone and the sialic acid residues was the best hemagglutinin inhibitor. Moreover, it exhibited promising interferon-inducing properties.
ISSN:0008-4166
DOI:10.1139/m91-035