High expression of AKR1B10 predicts low risk of early tumor recurrence in patients with hepatitis B virus-related hepatocellular carcinoma

• Published in: Scientific reports Vol. 7; no. 1; p. 42199
• Main Authors: Wang, Yan-Yan, Qi, Lu-Nan, Zhong, Jian-Hong, Qin, Hong-Gui, Ye, Jia-Zhou, Lu, Shi-Dong, Ma, Liang, Xiang, Bang-De, Li, Le-Qun, You, Xue-Mei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.02.2017; Nature Publishing Group
• Subjects: 13/1; 13/105; 13/51; 38/77; 38/79; 692/4020/4021/1607/1610/4029; 692/4028/67/1857; 82/80; Aldo-keto reductase; Gene expression; Hepatitis; Hepatitis B; Hepatocellular carcinoma; Humanities and Social Sciences; Immunohistochemistry; Liver cancer; Medical prognosis; multidisciplinary; Multivariate analysis; Polymerase chain reaction; Reverse transcription; Science; Survival; Western blotting; α-Fetoprotein
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep42199

To clarify the relationship between aldo-keto reductase family 1 member B10 (AKR1B10) expression and early hepatocellular carcinoma (HCC) recurrence, this study detected AKR1B10 expression in tumor and adjacent non-tumor tissues from 110 patients with hepatitis B virus (HBV)-related HCC underwent liver resection and analyzed its correlations with clinicopathological characteristics and prognosis of these patients. Detected by quantitative reverse transcription polymerase chain reaction, AKR1B10 mRNA expression showed significantly higher in HCC tissues than in adjacent non-tumor tissues, with a low level in normal liver tissues. Similar results was confirmed at the protein level using immunohistochemistry and Western blotting. High AKR1B10 expression was negatively correlated with serum alpha-fetoprotein level and positively correlated with HBV-DNA level. Patients with high AKR1B10 expression had significantly higher disease-free survival than those with low expression within 2 years after liver resection. Multivariate analysis also confirmed high AKR1B10 expression to be a predictor of low risk of early HCC recurrence. In addition, high AKR1B10 expression was found to be a favorable factor of overall survival. These results suggest that AKR1B10 is involved in HBV-related hepatocarcinogenesis, but its high expression could predict low risk of early tumor recurrence in patients with HBV-related HCC after liver resection.