Effect of Green Tea and Vitamin E Combination in Isoproterenol Induced Myocardial Infarction in Rats

• Published in: Plant foods for human nutrition (Dordrecht) Vol. 64; no. 1; pp. 75 - 80
• Main Authors: Upaganlawar, Aman, Gandhi, Chintan, Balaraman, Ramchandran
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.03.2009; Springer
• Subjects: Adenosine Triphosphatases - metabolism; Analysis of Variance; Animals; Antioxidants - pharmacology; Biological and medical sciences; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Coffee, tea and other stimulative beverage industries; Drug Synergism; Ecology; Food industries; Food Science; Fundamental and applied biological sciences. Psychology; Isoproterenol - toxicity; Lipid Peroxidation - drug effects; Male; Myocardial Infarction - chemically induced; Myocardial Infarction - prevention & control; Myocardium - enzymology; Myocardium - metabolism; Nutrition; Organ Size - drug effects; Original Paper; Oxidative Stress - drug effects; Plant Extracts - pharmacology; Plant Physiology; Random Allocation; Rats; Rats, Wistar; Tea - chemistry; Vitamin E - pharmacology; Weight Gain; Antioxidants; ATPases; Isoproterenol; Vitamin E; Green tea; Human; Rat; Enzyme; Body weight; Rodentia; Lipids; Marker; Antioxidant; Vertebrata; Mammalia; Endogenous; Adult; Membrane; Serum; Peroxidation
• ISSN: 0921-9668; 1573-9104
• DOI: 10.1007/s11130-008-0105-9

The present study was aimed to investigate the combined effects of green tea and vitamin E on heart weight, body weight, serum marker enzymes, lipid peroxidation, endogenous antioxidants and membrane bound ATPases in isoproterenol (ISO)-induced myocardial infarction in rats. Adult male albino rats, treated with ISO (200 mg/kg, s.c.) for 2 days at an interval of 24 h caused a significant ( P  < 0.05) elevation of heart weight, serum marker enzymes, lipid peroxidation and Ca +2 ATPase level whereas there was a significant ( P  < 0.05) decrease in body weight, endogenous antioxidants, Na + / K + ATPase and Mg +2 ATPase levels. Administration of green tea (100 mg/kg/day, p.o.) and vitamin E (100 mg/kg/day, p.o.) together for 30 consecutive days and challenged with ISO on the day 29th and 30th, showed a significant ( P  < 0.05) decrease in heart weight, serum marker enzymes, lipid peroxidation, Ca +2 ATPase and a significant increase in the body weight, endogenous antioxidants, Na + /K + ATPase and Mg +2 ATPase when compared with ISO treated group and green tea or vitamin E alone treated groups. These findings indicate the synergistic protective effect of green tea and vitamin E during ISO induced myocardial infarction in rats.