Association of rs2781666 G/T polymorphism of arginase I gene with myocardial infarction in Tunisian male population

The aim of this study was to investigate the association between rs2781666 G/T polymorphism of arginase I ( ARG I) gene and myocardial infarction (MI) in the Tunisian male population. Three hundred eighteen patients with MI and 282 controls were recruited. The rs2781666 G/T polymorphism of ARG I was...

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Published inClinical biochemistry Vol. 43; no. 1; pp. 106 - 109
Main Authors Sediri, Yousra, Kallel, Amani, Ben Ali, Samir, Omar, Souheil, Mourali, Mohamed Sami, Elasmi, Monia, Taieb, Sameh Haj, Sanhaji, Haïfa, Feki, Moncef, Mechmeche, Rachid, Jemaa, Riadh, Kaabachi, Naziha
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 2010
Elsevier
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Summary:The aim of this study was to investigate the association between rs2781666 G/T polymorphism of arginase I ( ARG I) gene and myocardial infarction (MI) in the Tunisian male population. Three hundred eighteen patients with MI and 282 controls were recruited. The rs2781666 G/T polymorphism of ARG I was determined by PCR-RFLP analysis. Patients had significantly higher frequency of TT genotype compared to controls (10.4% vs. 6.7%; p < 0.001). The MI patients showed higher frequency of T allele compared to the controls [0.33 vs. 0.22; OR (95% CI), 1.79 (1.37–2.34), p < 0.001]. The association between rs2781666 G/T polymorphism of ARG I gene and MI remained significant after adjustment for other well-established risk factors. A significant association between rs2781666 G/T polymorphism of ARG I gene and MI was found in the Tunisian male population.
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ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2009.10.058