Association of rs2781666 G/T polymorphism of arginase I gene with myocardial infarction in Tunisian male population

• Published in: Clinical biochemistry Vol. 43; no. 1; pp. 106 - 109
• Main Authors: Sediri, Yousra, Kallel, Amani, Ben Ali, Samir, Omar, Souheil, Mourali, Mohamed Sami, Elasmi, Monia, Taieb, Sameh Haj, Sanhaji, Haïfa, Feki, Moncef, Mechmeche, Rachid, Jemaa, Riadh, Kaabachi, Naziha
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 2010; Elsevier
• Subjects: Adult; Aged; Arginase - genetics; Arginase I; Biological and medical sciences; Cardiology. Vascular system; Coronary heart disease; Endothelial dysfunction; Genetic Predisposition to Disease; Genotype; Heart; Humans; Male; Medical sciences; Middle Aged; Myocardial infarction; Myocardial Infarction - enzymology; Myocardial Infarction - epidemiology; Myocardial Infarction - genetics; Nitric oxide; Polymorphism; Polymorphism, Single Nucleotide; Tunisia - epidemiology; Tunisia; Africa; Myocardial infarction; Endothelial dysfunction; Arginase I; Nitric oxide; Polymorphism; Human; Genetic variability; Enzyme; Cardiovascular disease; Arginase; Genotype; Male; Gene expression; Coronary heart disease; Myocardial disease; Genetic determinism; Risk factor; Molecular epidemiology; Hydrolases; Genetics
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2009.10.058

The aim of this study was to investigate the association between rs2781666 G/T polymorphism of arginase I ( ARG I) gene and myocardial infarction (MI) in the Tunisian male population. Three hundred eighteen patients with MI and 282 controls were recruited. The rs2781666 G/T polymorphism of ARG I was determined by PCR-RFLP analysis. Patients had significantly higher frequency of TT genotype compared to controls (10.4% vs. 6.7%; p < 0.001). The MI patients showed higher frequency of T allele compared to the controls [0.33 vs. 0.22; OR (95% CI), 1.79 (1.37–2.34), p < 0.001]. The association between rs2781666 G/T polymorphism of ARG I gene and MI remained significant after adjustment for other well-established risk factors. A significant association between rs2781666 G/T polymorphism of ARG I gene and MI was found in the Tunisian male population.