Efficacy of photodynamic therapy for treatment of basal cell carcinoma in organ transplant recipients

Photodynamic therapy (PDT) is an established treatment for superficial basal cell carcinoma (BCC). Organ transplant recipients (OTRs) are at increased risk of BCC. We investigated the efficacy of PDT in OTRs and compared the recurrence rate to the non-transplanted population. We conducted a retrospe...

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Bibliographic Details
Published inLasers in medical science Vol. 30; no. 4; pp. 1407 - 1409
Main Authors Collier, N. J., Ali, F. R., Lear, J. T.
Format Journal Article
LanguageEnglish
Published London Springer London 01.05.2015
Springer Nature B.V
Subjects
Aged
Aminolevulinic Acid - analogs & derivatives
Aminolevulinic Acid - therapeutic use
Blood & organ donations
Body centered cubic lattice
Brief Report
Carcinoma, Basal Cell - drug therapy
Carcinoma, Basal Cell - pathology
Clinical outcomes
Dentistry
Drug Screening Assays, Antitumor
Effectiveness
Female
Humans
Kidney Transplantation
Lasers
Male
Medicine
Medicine & Public Health
Middle Aged
Optical Devices
Optics
Organs
Patients
Photochemotherapy
Photodynamic therapy
Photonics
Photosensitizing Agents - therapeutic use
Quantum Optics
Retrospective Studies
Risk
Skin cancer
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Transplant Recipients
Transplants
Treatment Outcome
Organ transplant recipients
Photodynamic therapy
Basal cell carcinoma
Non-melanoma skin cancer
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Summary:Photodynamic therapy (PDT) is an established treatment for superficial basal cell carcinoma (BCC). Organ transplant recipients (OTRs) are at increased risk of BCC. We investigated the efficacy of PDT in OTRs and compared the recurrence rate to the non-transplanted population. We conducted a retrospective casenote review of all patients undergoing PDT for the treatment of BCC in our centre from 2003 to 2013. Three hundred and twenty-two BCCs from 103 patients underwent PDT during this period. There is no significant difference in BCC recurrence following PDT in OTRs (22.6 %) versus non-transplant patients (15.2 %) ( p  = 0.18). PDT is an efficacious treatment for BCC in OTRs with no significant evidence of inferiority compared to non-transplanted patients. Our findings require corroboration in a larger study.
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ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-013-1454-7