Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hor...

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Published inScientific reports Vol. 5; no. 1; p. 11525
Main Authors Jansen, S. W., Akintola, A. A., Roelfsema, F., van der Spoel, E., Cobbaert, C. M., Ballieux, B. E., Egri, P., Kvarta-Papp, Z., Gereben, B., Fekete, C., Slagboom, P. E., van der Grond, J., Demeneix, B. A., Pijl, H., Westendorp, R. G. J., van Heemst, D.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 19.06.2015
Nature Publishing Group
Subjects
631/443/319/1557
631/443/319/1842
631/443/7
Aged, 80 and over
Biological activity
Body temperature
Comorbidity
Energy Metabolism
Family
Female
Humanities and Social Sciences
Humans
Hypothalamic-pituitary-thyroid axis
Hypothalamo-Hypophyseal System - metabolism
Hypothalamus
Iodine - metabolism
Longevity
Male
Metabolic rate
Metabolism
multidisciplinary
Nonagenarian
Offspring
Pituitary
Risk Factors
Science
Secretion
Temperature
Temperature effects
Thyroid
Thyroid gland
Thyroid Hormones - blood
Thyroid Hormones - metabolism
Thyroid-stimulating hormone
Thyrotropin - blood
Thyrotropin - secretion
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Summary:Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism.
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These authors contributed equally to this work.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep11525