EFFECTS OF INCREMENTAL DOSES OF ALFENTANIL AND PROPOFOL ON THE BREATHING OF ANAESTHETIZED PATIENTS

• Published in: British journal of anaesthesia : BJA Vol. 63; no. 5; pp. 548 - 553
• Main Authors: GOODMAN, N.W., VANNER, R.G., WADE, J.A.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.11.1989; Oxford University Press
• Subjects: Adult; Alfentanil - pharmacology; Anesthesia, General; Biological and medical sciences; Drug toxicity and drugs side effects treatment; Humans; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Propofol - pharmacology; Respiration - drug effects; Tidal Volume - drug effects; Time Factors; Toxicity: respiratory system, ent, stomatology; Human; Drug combination; Analgesic; Lung function; General anesthetic; Toxicity; Surgery; Respiratory system; Dose activity relation

Incremental doses of alfentanil and propofol were given to anaesthetized healthy patients undergoing routine orthopaedic surgery. Ventilation was recorded by respiratory inductance plethysmography and analysed by microcomputer. Alfentanil affected primarily expiratory time. The onset of effect laste...