EFFECTS OF INCREMENTAL DOSES OF ALFENTANIL AND PROPOFOL ON THE BREATHING OF ANAESTHETIZED PATIENTS
Incremental doses of alfentanil and propofol were given to anaesthetized healthy patients undergoing routine orthopaedic surgery. Ventilation was recorded by respiratory inductance plethysmography and analysed by microcomputer. Alfentanil affected primarily expiratory time. The onset of effect laste...
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Published in | British journal of anaesthesia : BJA Vol. 63; no. 5; pp. 548 - 553 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.11.1989
Oxford University Press |
Subjects | |
Online Access | Get full text |
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Summary: | Incremental doses of alfentanil and propofol were given to anaesthetized healthy patients undergoing routine orthopaedic surgery. Ventilation was recorded by respiratory inductance plethysmography and analysed by microcomputer. Alfentanil affected primarily expiratory time. The onset of effect lasted 82 s (range 25–173 s); offset was exponential, with a half-life of 146 s (range 62–260 s). Alfentanil also reduced tidal volume, but the effect was less obvious and less consistent. Propofol affected primarily tidal volume. The onset of effect lasted 34 s (range 17–69 s); offset was linear, with a time to 50% recovery of 92 s (range 47–161 s). Propofol had little effect on expiratory time. The drugs had little effect on inspiratory time. Three patients showed periods when the distribution of expiratory times was bimodal; the mechanism for this is unknown. |
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Bibliography: | ark:/67375/HXZ-D7QJF6X3-F istex:468D94C6F519B270111F41ADDE864D5945D6B2E1 ArticleID:63.5.548 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-0912 1471-6771 |
DOI: | 10.1093/bja/63.5.548 |