Association between Int7G24A rs334354 polymorphism and cancer risk: a meta-analysis of case-control studies

• Published in: Scientific reports Vol. 5; no. 1; p. 11350
• Main Authors: Wu, Weixiang, Tong, Yeqing, Wei, Xiaoyun, Zhao, Qiang, Pan, Xiaoqi, Yu, Guangxia, Lu, Qing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.06.2015; Nature Publishing Group
• Subjects: 631/208/205; 631/67/2324; 631/67/68/2486; 692/699/67/2195; Alleles; Cancer; Case studies; Case-Control Studies; Gene Expression; Gene polymorphism; Genetic Association Studies; Genetic Predisposition to Disease; Health risk assessment; Health risks; Humanities and Social Sciences; Humans; Introns; Meta-analysis; Models, Genetic; multidisciplinary; Mutation; Neoplasms - diagnosis; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Polymorphism, Genetic; Population genetics; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Receptors, Transforming Growth Factor beta - genetics; Receptors, Transforming Growth Factor beta - metabolism; Risk; Science; Signal Transduction; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - metabolism; Transforming growth factor-b
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep11350

Accumulating evidences have suggested the potential association between Int7G24A (rs334354) polymorphism and cancer risk. However, results from epidemiological studies are controversial. We thus conducted this meta-analysis to clarify the association. Relevant studies were identified on electronic databases according to the inclusion criteria. A total of 13 case-control studies containing 4092 cases and 5909 controls were included in our meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the association. The results of the overall population had suggested that Int7G24A polymorphism had an increased risk for cancer, reaching significant levels in the 2 genetic models (allele model, OR = 1.25, 95% CI 1.09-1.42, P  = 0.001; dominant model, OR = 1.24, 95% CI 1.06-1.46, P  < 0.008). Besides, significant association was found among Asian population (allele model, OR = 1.27, 95% CI 1.11-1.45, P  < 0.001; dominant model, OR = 1.28, 95% CI 1.11-1.49, P  < 0.001), whereas there was non-significant relationship detected among Caucasian population (allele model, OR = 1.08, 95% CI 0.92-1.26, P  = 0.352; dominant model, OR = 1.05, 95% CI 0.87-1.26, P  = 0.639). The present meta-analysis had suggested that Int7G24A polymorphism of gene TGFBR1 involved in the transforming growth factor beta (TGF-β) signaling pathway had a significantly increased risk for cancer development.