DNA methylation profiles in cancer diagnosis and therapeutics

Cancer initiation and proliferation is regulated by both epigenetic and genetic events with epigenetic modifications being increasingly identified as important targets for cancer research. DNA methylation catalyzed by DNA methyltransferases (DNMTs) is one of the essential epigenetic mechanisms that...

Full description

Saved in:
Bibliographic Details
Published inClinical and experimental medicine Vol. 18; no. 1; pp. 1 - 14
Main Authors Pan, Yunbao, Liu, Guohong, Zhou, Fuling, Su, Bojin, Li, Yirong
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.02.2018
Springer Nature B.V
Subjects
Apoptosis
Biomarkers
Cancer
Cell cycle
Cell proliferation
Deoxyribonucleic acid
Diagnosis
DNA
DNA methylation
Epigenetics
Genetic transformation
Hematology
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Precision medicine
Review Article
Tumorigenesis
DNMT inhibitor
DNA methylation
Epigenetics
Biomarker
Cancer
Online AccessGet full text

Cover

More Information
Summary:Cancer initiation and proliferation is regulated by both epigenetic and genetic events with epigenetic modifications being increasingly identified as important targets for cancer research. DNA methylation catalyzed by DNA methyltransferases (DNMTs) is one of the essential epigenetic mechanisms that control cell proliferation, apoptosis, differentiation, cell cycle, and transformation in eukaryotes. Recent progress in epigenetics revealed a deeper understanding of the mechanisms of tumorigenesis and provided biomarkers for early detection, diagnosis, and prognosis in cancer patients. Although DNA methylation biomarker possesses potential contributing to precision medicine, there are still limitations to be overcome before it reaches clinical setting. Hence, the current status of DNA methylation biomarkers was reviewed and the future use in clinic was also predicted.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1591-8890
1591-9528
DOI:10.1007/s10238-017-0467-0