Evaluation of developmental toxicity data: a discussion of some pertinent factors and a proposal

There is currently no well-accepted standard method for evaluation of developmental toxicity data. This paper presents one approach to the evaluation of developmental toxicity data. We initially identify some pertinent factors that influence the interpretation of animal data and summarize the litera...

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Published inRisk analysis Vol. 8; no. 1; p. 59
Main Authors Hart, W L, Reynolds, R C, Krasavage, W J, Ely, T S, Bell, R H, Raleigh, R L
Format Journal Article
LanguageEnglish
Published United States 01.03.1988
Subjects
Animals
Female
Fetus - drug effects
Humans
Occupational Diseases - chemically induced
Pregnancy
Prenatal Exposure Delayed Effects
Risk
Toxicology - methods
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Summary:There is currently no well-accepted standard method for evaluation of developmental toxicity data. This paper presents one approach to the evaluation of developmental toxicity data. We initially identify some pertinent factors that influence the interpretation of animal data and summarize the literature pertaining to these factors. Such factors include the quality and quantity of data and the relationship between maternal and developmental toxicity. We proceed with a discussion of quantitative assessment of data and propose schemes for qualitative and quantitative developmental hazard assessments.
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1988.tb01154.x