Mitochondrial spare respiratory capacity: Mechanisms, regulation, and significance in non-transformed and cancer cells

Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain bioenergetic levels related to cellular functions. This absence of proper adaptation can be seen in a wide array of conditions, including cancer. Metabolic adaptation calls on mitochondrial function and draws on...

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Bibliographic Details
Published inThe FASEB journal Vol. 34; no. 10; p. 13106
Main Authors Marchetti, Philippe, Fovez, Quentin, Germain, Nicolas, Khamari, Raeeka, Kluza, Jérôme
Format Journal Article
LanguageEnglish
Published United States 01.10.2020
Subjects
Animals
Cell Respiration
Humans
Mitochondria - metabolism
Neoplasms - metabolism
Oxygen Consumption
mitochondrial adaptation
spare reserve capacity
uncoupling ratio
oxygen consumption
mitochondrial flexibility
mitochondrial dysfunction
respiratory reserve capacity
mitochondrial stress
mitochondrial metabolism
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Summary:Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain bioenergetic levels related to cellular functions. This absence of proper adaptation can be seen in a wide array of conditions, including cancer. Metabolic adaptation calls on mitochondrial function and draws on the mitochondrial reserve to meet increasing needs. Among mitochondrial respiratory parameters, the spare respiratory capacity (SRC) represents a particularly robust functional parameter to evaluate mitochondrial reserve. We provide an overview of potential SRC mechanisms and regulation with a focus on its particular significance in cancer cells.
ISSN:1530-6860
DOI:10.1096/fj.202000767R