Experimental infection of chimpanzees with the HBsAg-associated delta (delta) agent: an ultrastructural study

Characteristic cytoplasmic membranous structures and intranuclear aggregates of particles similar to those reported in non-A, non-B hepatitis were observed by electron microscopy in the liver biopsies of chimpanzees inoculated with human serum, infectious for the delta agent. The ultrastructural cha...

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Bibliographic Details
Published inJournal of medical virology Vol. 13; no. 1; p. 63
Main Authors Canese, M G, Rizzetto, M, Novara, R, London, W T, Purcell, R H
Format Journal Article
LanguageEnglish
Published United States 1984
Subjects
Alanine Transaminase - blood
Animals
Antigens, Viral - analysis
Cell Nucleus - pathology
Cell Nucleus - ultrastructure
Cytoplasm - pathology
Cytoplasm - ultrastructure
Hepatitis - pathology
Hepatitis B - pathology
Hepatitis B Antigens - analysis
Hepatitis B Core Antigens - analysis
Hepatitis B Surface Antigens - analysis
Hepatitis C - pathology
Hepatitis delta Antigens
Humans
Liver - pathology
Liver - ultrastructure
Microscopy, Electron
Pan troglodytes
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Summary:Characteristic cytoplasmic membranous structures and intranuclear aggregates of particles similar to those reported in non-A, non-B hepatitis were observed by electron microscopy in the liver biopsies of chimpanzees inoculated with human serum, infectious for the delta agent. The ultrastructural changes were maximal during the intrahepatic production of the delta antigen, but were detected also independently of delta-Ag expression. The ultrastructural analogies provide further evidence that delta has properties distinct from HBV.
ISSN:0146-6615
DOI:10.1002/jmv.1890130108