Relationship between progesterone suppression and pregnancy in rats

Four luteolytic agents were administered to groups of pregnant rats to examine the quantitative relationship between serum progesterone levels and the maintenance of pregnancy. Each agent inhibited progesterone in a dose-dependent manner, however only three, azastene, thiosemicarbazone and dihydrote...

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Bibliographic Details
Published inJournal of pharmacy and pharmacology Vol. 39; no. 5; p. 401
Main Authors Carnathan, G W, Metcalf, L E, Cochrane, R L, Nutting, E F, Black, D L
Format Journal Article
LanguageEnglish
Published England 01.05.1987
Subjects
Animals
Female
Luteolytic Agents - pharmacology
Pregnancy
Pregnancy, Animal - blood
Pregnancy, Animal - drug effects
Progesterone - blood
Radioimmunoassay
Rats
Rats, Inbred Strains
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Summary:Four luteolytic agents were administered to groups of pregnant rats to examine the quantitative relationship between serum progesterone levels and the maintenance of pregnancy. Each agent inhibited progesterone in a dose-dependent manner, however only three, azastene, thiosemicarbazone and dihydrotestosterone, adversely affected pregnancy. A statistical analysis of the data suggests that, regardless of the mechanism of action of a particular luteolytic agent, a treatment-induced depression of serum progesterone to concentrations less than 45% of that of the controls on day 11 of pregnancy is incompatible with pregnancy maintenance.
ISSN:0022-3573
DOI:10.1111/j.2042-7158.1987.tb03408.x