Relaxin Receptor LGR7 (RXFP1) Is Regulated by Estrogen

Estrogen regulates LGR7 (RXFP1) mRNA expression in an in vitro model of human term pregnancy cervix that utilizes lower uterine segment fibroblasts. LGR7 mRNA levels were increased by estradiol to mean levels of 152%± 5.9% above those in untreated control cells. Therefore, estradiol may amplify rela...

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Published inAnnals of the New York Academy of Sciences Vol. 1160; no. 1; pp. 91 - 92
Main Authors Maseelall, Priya, Gardner, Jeff, Wojtczuk, Andrea, Weiss, Gerson, Goldsmith, Laura T.
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.04.2009
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Summary:Estrogen regulates LGR7 (RXFP1) mRNA expression in an in vitro model of human term pregnancy cervix that utilizes lower uterine segment fibroblasts. LGR7 mRNA levels were increased by estradiol to mean levels of 152%± 5.9% above those in untreated control cells. Therefore, estradiol may amplify relaxin's actions in the cervix.
Bibliography:istex:46BBF6ACDDB0A06535D2924EB3A001D93098E34E
ark:/67375/WNG-F2CK13S1-9
ArticleID:NYAS04048
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2009.04048.x