Acebutolol overdose treated with hemodialysis and extracorporeal membrane oxygenation

A case involving a 27-year-old woman who ingested an overdose of acebutolol is presented. Extracorporeal membrane oxygenation was initiated to stabilize the patient's condition before commencing hemodialysis. S-diacetolol (the N-acetelation product of acebutolol) was cleared with hemodialysis....

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Bibliographic Details
Published inJournal of clinical pharmacology Vol. 36; no. 8; p. 760
Main Authors Rooney, M, Massey, K L, Jamali, F, Rosin, M, Thomson, D, Johnson, D H
Format Journal Article
LanguageEnglish
Published England 01.08.1996
Subjects
Acebutolol - blood
Acebutolol - poisoning
Adrenergic beta-Antagonists - blood
Adrenergic beta-Antagonists - poisoning
Adult
Drug Overdose - therapy
Extracorporeal Membrane Oxygenation
Female
Humans
Renal Dialysis
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Summary:A case involving a 27-year-old woman who ingested an overdose of acebutolol is presented. Extracorporeal membrane oxygenation was initiated to stabilize the patient's condition before commencing hemodialysis. S-diacetolol (the N-acetelation product of acebutolol) was cleared with hemodialysis. It is suggested that extracorporeal membrane oxygenation may be of short-term benefit in the treatment of overdoses with beta-adrenergic agents such as acebutolol when accelerated clearance with hemodialysis is anticipated.
ISSN:0091-2700
DOI:10.1002/j.1552-4604.1996.tb04247.x