Salmeterol inhibits anaphylactic histamine release from guinea-pig isolated mast cells

Salmeterol (1 nM-100 microM) showed an inhibitory action on anaphylactic histamine release from mast cells, isolated from pleural and peritoneal cavities of actively sensitized guinea-pigs and stimulated by incubation with allergen. The effect is concentration-dependent and is reduced by the beta-ad...

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Bibliographic Details
Published inJournal of pharmacy and pharmacology Vol. 46; no. 1; p. 76
Main Authors Gentilini, G, Grazia di Bello, M, Raspanti, S, Bindi, D, Mugnai, S, Zilletti, L
Format Journal Article
LanguageEnglish
Published England 01.01.1994
Subjects
Adrenergic beta-Agonists - pharmacology
Albuterol - analogs & derivatives
Albuterol - pharmacology
Anaphylaxis - drug therapy
Animals
Fluorometry
Guinea Pigs
Histamine Antagonists - pharmacology
Histamine Release - drug effects
In Vitro Techniques
Male
Mast Cells - drug effects
Peritoneal Cavity - cytology
Pleura - cytology
Propranolol - pharmacology
Salmeterol Xinafoate
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Summary:Salmeterol (1 nM-100 microM) showed an inhibitory action on anaphylactic histamine release from mast cells, isolated from pleural and peritoneal cavities of actively sensitized guinea-pigs and stimulated by incubation with allergen. The effect is concentration-dependent and is reduced by the beta-adrenoceptor antagonist propranolol (1 microM). This study supports the hypothesis of an anti-inflammatory property of salmeterol, which concerns cells involved in the early phases of asthma.
ISSN:0022-3573
DOI:10.1111/j.2042-7158.1994.tb03725.x