Comparison of two methods for INR determination in a pharmacist-based oral anticoagulation clinic

• Published in: Pharmacotherapy Vol. 16; no. 6; p. 1159
• Main Authors: Yamreudeewong, W, Johnson, J V, Cassidy, T G, Berg, J T
• Format: Journal Article
• Language: English
• Published: United States 01.11.1996
• Subjects: Aged; Aged, 80 and over; Anticoagulants - administration & dosage; Drug Monitoring - methods; Heart Diseases - drug therapy; Hospitals, Veterans; Humans; Male; Middle Aged; Outpatient Clinics, Hospital; Patient Acceptance of Health Care; Patient Satisfaction; Prothrombin Time; Thrombosis - drug therapy; Warfarin - administration & dosage; Wyoming; Wyoming
• ISSN: 0277-0008
• DOI: 10.1002/j.1875-9114.1996.tb03045.x

Warfarin is a commonly used oral anticoagulant that is usually initiated after the definitive diagnosis of a certain thromboembolic disorder or disease. Warfarin therapy will usually be prescribed for 6-12 weeks or more, and some patients may continue therapy throughout life, depending on the type of thromboembolic disorder. Major problems associated with warfarin therapy include adverse effects such as bleeding complications and drug-drug or drug-food interactions. In addition, thromboembolic complications may occur due to subtherapeutic dosages of warfarin. The laboratory reference standards for monitoring warfarin therapy are the prothrombin time (PT) and the International Normalized Ratio (INR). While both the PT or INR will reflect the clinical response in the patient, results reported as INR values have been shown to be more accurate than those reported as PT values. Thirty-two patients were enrolled in this study. Our objectives were to compare INR values measured by both the Coumatrak and conventional laboratory method, and to demonstrate the effects of pharmacist intervention on managing patients receiving warfarin therapy. Results from our study reveal that INR monitoring by Coumatrak is similar to the conventional laboratory method. In addition, our study indicates that patients receiving warfarin therapy can be monitored and managed effectively by pharmacists.