Acute hepatitis B in infants born to HBsAG asymptomatic carrier mothers

Within an eight-month period, five cases of acute hepatitis B were observed in children born to asymptomatic HBsAg carrier mothers. At delivery, four mothers were HBeAg-positive and one was anti-HBe-positive. At an average age of 17+/-3 weeks the infants showed high transaminases levels and appearan...

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Bibliographic Details
Published inActa pædiatrica Scandinavica Vol. 71; no. 1; p. 115
Main Authors Moroni, G A, Chiccoli, C, Zanetti, A R, Angeli, M, Giunta, A M
Format Journal Article
LanguageEnglish
Published Sweden 01.01.1982
Subjects
Acute Disease
Carrier State
Female
Hepatitis B - genetics
Hepatitis B - immunology
Hepatitis B - transmission
Hepatitis B Surface Antigens
Humans
Infant
Infant, Newborn
Liver Function Tests
Male
Pregnancy
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Summary:Within an eight-month period, five cases of acute hepatitis B were observed in children born to asymptomatic HBsAg carrier mothers. At delivery, four mothers were HBeAg-positive and one was anti-HBe-positive. At an average age of 17+/-3 weeks the infants showed high transaminases levels and appearance of markers of HBV infection. Three children became HBsAG chronic carriers, one had a brief HBsAg-antigenemia (1 week), while the last one showed clinical and biochemical signs of hepatitis B in absence of detectable HBsAg but with anti-HBc and anti-HBe (window phase) and later became anti-HBs-positive.
ISSN:0001-656X
DOI:10.1111/j.1651-2227.1982.tb09381.x