Excretion of cytomegalovirus in semen associated with HTLV-III seropositivity in asymptomatic homosexual men

We studied 56 asymptomatic homosexual male volunteers in Pittsburgh for 1 1/2 yr for relationships between cytomegalovirus (CMV) and human T-lymphotropic virus type III (HTLV-III) infections. CMV was most frequently isolated from semen (8%) as compared with throat washings (5.9%) and urine (0%) on i...

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Bibliographic Details
Published inJournal of medical virology Vol. 20; no. 1; p. 17
Main Authors Rinaldo, Jr, C R, Kingsley, L A, Lyter, D W, Bodner, A J, Weiss, S H, Saxinger, W C
Format Journal Article
LanguageEnglish
Published United States 01.09.1986
Subjects
Acquired Immunodeficiency Syndrome - complications
Adolescent
Adult
Antibodies, Viral - analysis
Cytomegalovirus - isolation & purification
Cytomegalovirus Infections - complications
HIV - immunology
HIV Antibodies
Homosexuality
Humans
Male
Middle Aged
Semen - microbiology
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Summary:We studied 56 asymptomatic homosexual male volunteers in Pittsburgh for 1 1/2 yr for relationships between cytomegalovirus (CMV) and human T-lymphotropic virus type III (HTLV-III) infections. CMV was most frequently isolated from semen (8%) as compared with throat washings (5.9%) and urine (0%) on initial testing of CMV-seropositive subjects. Other viruses commonly isolated from immunosuppressed patients (herpes simplex virus, adenovirus) were rarely detected in this cohort. Seropositivity to HTLV-III was significantly associated with isolation of CMV from semen in our asymptomatic cohort (odds ratio = 9.5, p = .008). These results suggest that HTLV-III infection is associated with selective, temporal activation of CMV in the genital tract of asymptomatic homosexual men.
ISSN:0146-6615
DOI:10.1002/jmv.1890200104