Longitudinal advanced MRI case report of white matter radiation necrosis
Radiation necrosis mostly occurs in and near the radiation field. We used magnetic resonance imaging to study radiation‐induced necrosis of atypical onset, severity, and extent following stereotactic radiosurgery for a symptomatic arteriovenous malformation. Susceptibility‐sensitive imaging, T1‐rela...
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Published in | Annals of clinical and translational neurology Vol. 6; no. 2; pp. 379 - 385 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
John Wiley & Sons, Inc
01.02.2019
John Wiley and Sons Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Radiation necrosis mostly occurs in and near the radiation field. We used magnetic resonance imaging to study radiation‐induced necrosis of atypical onset, severity, and extent following stereotactic radiosurgery for a symptomatic arteriovenous malformation. Susceptibility‐sensitive imaging, T1‐relaxation, myelin water imaging, and magnetic resonance spectroscopy were acquired three times up to 52 months postradiosurgery. Increasing water content outside the radiation field, contralateral neuronal loss, and gliosis were detected over time. Our findings suggest that radiation‐induced vasculopathic changes spread more diffusely than previously described. An autoimmune response to brain antigens could underlie white matter changes outside the initial radiation field. |
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Bibliography: | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 These authors contributed equally to the manuscript. Funding Information This study was in part supported by the German Academic Exchange Service (DAAD). This work has been presented in an abstract form (poster presentation) at the 69th Annual American Academy of Neurology meeting in Boston, April 2017. |
ISSN: | 2328-9503 2328-9503 |
DOI: | 10.1002/acn3.704 |