The production of hepatic cirrhosis in rats

This study investigated the conditions necessary to produce a predictable yield of cirrhosis in rats. A previously published method, using carbon tetrachloride, was used as a basis for the study. Histopathology was used in a semi-quantitative manner to examine which observations could be used for th...

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Bibliographic Details
Published inJournal of applied toxicology Vol. 11; no. 3; p. 229
Main Authors Tomaszewski, K E, Harries, G C, Jeffrey, P
Format Journal Article
LanguageEnglish
Published England 01.06.1991
Subjects
Animals
Body Weight - drug effects
Carbon Tetrachloride - toxicity
Fibrosis
Hyperplasia
Hypertrophy
Liver - drug effects
Liver - pathology
Liver Cirrhosis, Experimental - chemically induced
Male
Necrosis
Rats
Rats, Inbred Strains
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Summary:This study investigated the conditions necessary to produce a predictable yield of cirrhosis in rats. A previously published method, using carbon tetrachloride, was used as a basis for the study. Histopathology was used in a semi-quantitative manner to examine which observations could be used for the prediction of progression and final yield of cirrhosis. A comparison of different vehicles for oral carbon tetrachloride administration showed no effect of vehicle on the final yield of cirrhosis. Also, there were no observations during the study that should be used for prediction. Variability in the severity of hepatic impairment is an inherent feature of this model, and supporting histopathology is essential. We recommend a simple protocol for the initiation of cirrhosis in rats using carbon tetrachloride.
ISSN:0260-437X
DOI:10.1002/jat.2550110313