Influence of food on the oral absorption and bioavailability of moricizine

Moricizine, a unique Class I antiarrhythmic agent, was orally administered with and without a meal to 24 healthy male subjects to determine the effect of food on moricizine absorption and bioavailability. Relative to the fasting state, a standardized breakfast delayed the time to peak plasma moriciz...

Full description

Saved in:
Bibliographic Details
Published inJournal of clinical pharmacology Vol. 31; no. 9; p. 792
Main Authors Pieniaszek, Jr, H J, Rakestraw, D C, Schary, W L, Williams, R L
Format Journal Article
LanguageEnglish
Published England 01.09.1991
Subjects
Administration, Oral
Adolescent
Adult
Biological Availability
Fasting - metabolism
Food
Humans
Intestinal Absorption - physiology
Male
Moricizine - administration & dosage
Moricizine - blood
Moricizine - pharmacokinetics
Time Factors
Online AccessGet more information

Cover

More Information
Summary:Moricizine, a unique Class I antiarrhythmic agent, was orally administered with and without a meal to 24 healthy male subjects to determine the effect of food on moricizine absorption and bioavailability. Relative to the fasting state, a standardized breakfast delayed the time to peak plasma moricizine concentration (1.2 vs. 0.9 hr; P less than .03) and lowered peak plasma moricizine concentration by 24% (0.55 vs. 0.72 microgram/mL; P less than .03). Bioavailability, as measured by area under the plasma moricizine concentration versus time curve, was not significantly altered by the meal.
ISSN:0091-2700
1552-4604
DOI:10.1002/j.1552-4604.1991.tb01912.x