Lymphocyte Subset Counts in COVID‐19 Patients: A Meta‐Analysis

A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized coronavirus disease 2019 (COVID‐19) patients. In this brief meta‐analysis, the reduction of lymphocyte subset counts in COVID‐19 patients was investigated across 2...

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Published inCytometry. Part A Vol. 97; no. 8; pp. 772 - 776
Main Authors Huang, Wei, Berube, Julie, McNamara, Michelle, Saksena, Suraj, Hartman, Marsha, Arshad, Tariq, Bornheimer, Scott J., O'Gorman, Maurice
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.08.2020
Wiley Subscription Services, Inc
Subjects
B-Lymphocytes - cytology
Betacoronavirus
CD4 antigen
CD4-Positive T-Lymphocytes - cytology
CD8 antigen
CD8-Positive T-Lymphocytes - cytology
Cell number
Coronavirus Infections - blood
Coronaviruses
COVID-19
COVID‐19 Fast Track
Cytometry
flow cytometry
Humans
immunophenotyping
Killer Cells, Natural - cytology
Lymphocyte Count
lymphocyte subset
Lymphocytes
Lymphocytes T
Meta-analysis
Multivariate analysis
Natural killer cells
Neutrophils - cytology
Pandemics
Peripheral blood
Pneumonia, Viral - blood
Reduction
Review
SARS-CoV-2
Statistical analysis
T-Lymphocyte Subsets - cytology
T‐cell subset
Viral diseases
COVID-19
lymphocyte subset
flow cytometry
T-cell subset
immunophenotyping
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Summary:A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized coronavirus disease 2019 (COVID‐19) patients. In this brief meta‐analysis, the reduction of lymphocyte subset counts in COVID‐19 patients was investigated across 20 peer‐reviewed studies meeting criteria for reporting lymphocyte subset counts and COVID‐19 disease severity. CD4+ T cell, CD8+ T cell, B cell, NK cell, and total lymphocyte cell counts all showed statistically significant reduction in patients with severe/critical COVID‐19 disease compared to mild/moderate disease. T‐cell subsets showed the largest standardized magnitude of change. In some studies, multivariate analysis has shown that CD4 and/or CD8 T‐cells counts are independently predictive of patient outcomes. © 2020 International Society for Advancement of Cytometry
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ISSN:1552-4922
1552-4930
1552-4930
DOI:10.1002/cyto.a.24172