AROMATIC AND AZAAROMATIC DISELENIDES, BENZISOSELENAZOLONES AND RELATED-COMPOUNDS AS IMMUNOMODULATORS ACTIVE IN HUMANS - SYNTHESIS AND PROPERTIES

Convenient syntheses of aryl diselenides 2, 1,2-benzisoselenazol-3(2H)-ones 4 and their 1-oxides 7 are reported. Reductive conversions of these compounds to bis(2-carbamoyl)-phenyl diselenides 5 and oxidative cyclization of 5 to 1,2-benzisoselenazol-3(2H)-one 1-oxides 7 as the methods for the synthe...

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Bibliographic Details
Published inLiebigs Annalen der Chemie no. 12; pp. 1239 - 1244
Main Authors MLOCHOWSKI, J, KLOC, K, SYPER, L, INGLOT, AD, PIASECKI, E
Format Journal Article
LanguageEnglish
Published DEERFIELD BEACH Wiley 13.12.1993
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
OXIDATION
GLUTATHIONE-PEROXIDASE
PZ-51 EBSELEN
9-OXO-10-ACRIDINEACETIC ACID
DISELENIDES
ORGANIC DISELENIDES
CYTOKINE INDUCERS
INTERFERON-GAMMA
TUMOR NECROSIS FACTOR
ORGANOSELENIUM COMPOUND
SELENIUM-COMPOUNDS
1,2-BENZISOSELENAZOL-3(2H)-ONES
HYDROGEN-PEROXIDE
PEROXIDASE-LIKE ACTIVITY
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Summary:Convenient syntheses of aryl diselenides 2, 1,2-benzisoselenazol-3(2H)-ones 4 and their 1-oxides 7 are reported. Reductive conversions of these compounds to bis(2-carbamoyl)-phenyl diselenides 5 and oxidative cyclization of 5 to 1,2-benzisoselenazol-3(2H)-one 1-oxides 7 as the methods for the synthesis of these compounds are reported. Their ability to induce cytokines, such as TNF and IFN-gamma, in human peripheral blood leucocyte cultures is described.
ISSN:0170-2041
DOI:10.1002/jlac.1993199301201