Apo E genotypes and risk of dementia in Down syndrome

The relationship between apo E genotypes and risk of dementia in Down syndrome is not clear. Accordingly, we have analysed this locus in 20 demented and 25 nondemented individuals with Down syndrome and combined these data with other studies in a meta-analysis. The meta-analysis revealed an estimate...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of medical genetics Vol. 88; no. 4; p. 344
Main Authors Rubinsztein, D C, Hon, J, Stevens, F, Pyrah, I, Tysoe, C, Huppert, F A, Easton, D F, Holland, A J
Format Journal Article
LanguageEnglish
Published United States 20.08.1999
Subjects
Adult
Alzheimer Disease - epidemiology
Alzheimer Disease - genetics
Apolipoproteins E - genetics
Comorbidity
Dementia - epidemiology
Dementia - genetics
Down Syndrome - epidemiology
Down Syndrome - genetics
Female
Genotype
Humans
Male
Middle Aged
Models, Statistical
Risk Factors
Online AccessGet more information

Cover

More Information
Summary:The relationship between apo E genotypes and risk of dementia in Down syndrome is not clear. Accordingly, we have analysed this locus in 20 demented and 25 nondemented individuals with Down syndrome and combined these data with other studies in a meta-analysis. The meta-analysis revealed an estimated odds ratio for dementia of 2.74 (95% CI 1.34-5.58) (P =.0004) for apo epsilon4 carriers compared with apo epsilon3/epsilon3, similar to that observed in late-onset Alzheimer's disease. An additional parallel with late-onset Alzheimer's disease was shown by the apo epsilon2 allele, which was associated with decreased dementia risk in Down syndrome (odds ratio for apo epsilon2/epsilon2 + epsilon2/epsilon3 = 0.37 (95% CI 0.14-0. 96)). Thus, apo E genotypes are associated with similar risk effects in Down syndrome dementia and late-onset Alzheimer's disease.
ISSN:0148-7299
DOI:10.1002/(SICI)1096-8628(19990820)88:4<344::AID-AJMG10>3.0.CO;2-1