HLA-B SNA antigen: a BW6 associated B locus antigen belonging to the B5 CREG

A new B locus antigen has been found in members of two unrelated families and in a patient originating from Morocco belonging to the Berber population. A complete analysis has been performed with antisera from the 9th and 10th IHWS defining the B5 CREG antigens. Serology, absorption experiments and...

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Bibliographic Details
Published inTissue antigens Vol. 33; no. 3; p. 400
Main Authors Andrien, M, Reekers, P, Stordeur, P, Vandercruys, M, Dupont, E
Format Journal Article
LanguageEnglish
Published England 01.03.1989
Subjects
Cross Reactions
Cytotoxicity, Immunologic
Histocompatibility Testing - methods
HLA-B Antigens - analysis
Humans
Immunochemistry
Isoelectric Point
Pedigree
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Summary:A new B locus antigen has been found in members of two unrelated families and in a patient originating from Morocco belonging to the Berber population. A complete analysis has been performed with antisera from the 9th and 10th IHWS defining the B5 CREG antigens. Serology, absorption experiments and family studies indicate that SNA antigen is a Bw6 associated subtype of B5 antigen closely related to but clearly distinct from each of the B5 CREG antigens. One-dimensional isoelectric focusing study (1D-IEF) confirms that the SNA antigen precipitates as a B locus gene product and has an isoelectric point identical to that of Bw52 and one of the charge variants of B51.
ISSN:0001-2815
DOI:10.1111/j.1399-0039.1989.tb01683.x