Interleukin-18 promoter gene -607C/A polymorphism and tuberculosis risk： a meta-analysis

• Published in: Chinese medical journal Vol. 126; no. 17; pp. 3360 - 3363
• Main Authors: Li, Dian-Dian, Jia, Liu-Qun, Guo, Shu-Jin, Shen, Yong-Chun, Wen, Fu-Qiang
• Format: Journal Article
• Language: English
• Published: China Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan 610041, China 2013; Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
• Subjects: Genetic Predisposition to Disease - genetics; Humans; IL-18; Interleukin-18 - genetics; Meta分析; Promoter Regions, Genetic - genetics; Tuberculosis - epidemiology; Tuberculosis - genetics; 基因启动子; 多态性; 白细胞介素18; 等位基因; 结核病; 风险; meta-analysis; polymorphism; interleukin-18; tuberculosis
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20130550

Background Numerous studies have evaluated the association between interleukin-18 （IL-18） promoter gene -607C/ A （rs1946518） polymorphism and tuberculosis （TB） risk. However, the results remain apparently conflicting. The aim of this study was to investigate whether IL-18-607C/A polymorphism is associated with susceptibility to TB. Methods Publications addressing the association between the IL-18-607C/A polymorphism and TB risk were selected from the Pubmed, Cochrane Library, Embase, CNKI and Wanfang databases. Data were extracted from the studies by two independent reviewers. Statistical analysis was performed using RevMan 5.0.25 and STATA 11.0 software. Results Eight case-control studies with a total of 1166 TB patients and 1734 controls were retrieved. Meta-analysis results showed significant association between IL-18-607C/A polymorphism and TB risk in all comparisons of the A allele versus C allele （0R=1.17, 95% CI 1.05-1.30, P=0.004）, AA versus CC （0R=1.43, 95% CI 1.14-1.81, P=0.002）, CA＋AA versus CC （OR=1.20, 95% CI 1.01-1.42, P=0.04） and AA versus CA＋CC （OR=1.30, 95% CI 1.07-1.58, P=0.007）. In subgroup analysis by nationality, a significant association between IL-18-607C/A polymorphism and TB risk in the comparisons of A versus C, CA＋AA versus CC and AA versus CA＋CC （0R=1.22, 95% CI 1.07-1.38, P=0.002; OR=1.31, 95% CI 1.06-1.61, P=0.01; OR=1.32, 95% CI 1.07-1.63, P=0.01, respectively） were found in Chinese population but not in Indian and Iranian populations. Conclusion This study suggests that the -607C/A polymorphism of IL-18 gene would be a risk factor for TB, especially in Chinese population. To further evaluate gene-to-gene and gene-to-environment interactions on -607C/A polymorphism and tuberculosis risk, more studies with thousands of patients are required.