The direct catalytic asymmetric aldol reaction

Asymmetric aldol reactions are a powerful method for the construction of carbon-carbon bonds in an enantioselective fashion. Historically this reaction has been performed in a stoichiometric fashion to control the various aspects of chemo-, diastereo-, regio- and enantioselectivity, however, a more...

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Bibliographic Details
Published inChemical Society reviews Vol. 39; no. 5; pp. 1600 - 1632
Main Authors Trost, Barry M, Brindle, Cheyenne S
Format Journal Article
LanguageEnglish
Published England 01.01.2010
Subjects
Alcohols - chemistry
Catalysis
Ketones - chemistry
Metals - chemistry
Stereoisomerism
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Summary:Asymmetric aldol reactions are a powerful method for the construction of carbon-carbon bonds in an enantioselective fashion. Historically this reaction has been performed in a stoichiometric fashion to control the various aspects of chemo-, diastereo-, regio- and enantioselectivity, however, a more atom economical approach would unite high selectivity with the use of only a catalytic amount of a chiral promoter. This critical review documents the development of direct catalytic asymmetric aldol methodologies, including organocatalytic and metal-based strategies. New methods have improved the reactivity, selectivity and substrate scope of the direct aldol reaction and enabled the synthesis of complex molecular targets (357 references).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-2
ISSN:0306-0012
1460-4744
DOI:10.1039/b923537j