Responses of the rotifer Brachionus plicatilis to flame retardant (BDE-47) stress

• Published in: Marine pollution bulletin Vol. 116; no. 1-2; pp. 298 - 306
• Main Authors: Jian, Xiaoyang, Tang, Xuexi, Xu, Ningning, Sha, Jingjing, Wang, You
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.03.2017
• Subjects: 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47); Animals; Antioxidant enzymatic system; Antioxidants - metabolism; Brachionus plicatilis; Flame Retardants - toxicity; Glutathione - metabolism; Halogenated Diphenyl Ethers - toxicity; Marine zooplankton; Oxidative Stress; Reactive oxygen species (ROS); Reactive Oxygen Species - metabolism; Rotifera - drug effects; Toxicity Tests; Water Pollutants, Chemical - toxicity; Xenobiotic-metabolizing enzymatic system; Brachionus plicatilis; Antioxidant enzymatic system; Xenobiotic-metabolizing enzymatic system; Marine zooplankton; 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47); Reactive oxygen species (ROS)
• ISSN: 0025-326X; 1879-3363
• DOI: 10.1016/j.marpolbul.2017.01.015

A series of short-term toxicological tests were conducted on the rotifer Brachionus plicatilis to assess the toxicity of the flame retardant 2,2′,4,4′-tetrabrominated biphenyl ether (BDE-47). BDE-47 increased mortality, morphological damage, and altered population dynamics and fecundity of rotifer. Antioxidant enzymes were differentially changed to maintain the balance between antioxidant and pro-oxidant activity. However, with increases in the concentration of BDE-47, the metabolic and antioxidant activity decreased. Moreover, the reactive oxygen species (ROS) and malondialdehyde contents increased and the ratio between glutathione and glutathione-SH decreased, indicating oxidative stress. The addition of the ROS-inhibitor N-acetylcysteine alleviated the degree of damage and stimulated the activity of xenobiotic-metabolizing and antioxidant system, which suggested that ROS were the most important loop in the stress response. •Responses of xenobiotic-metabolizing and antioxidant system to BDE-47 were assessed in rotifer.•Activated Phase I could orderly stimulate Phase II to accelerate the detoxification.•Main components of antioxidant system changed at different levels.•Population dynamic and reproduction varied with detoxifying system and ROS production.•NAC addition implied ROS were the most essential loop in the stress induced by BDE-47.