In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood

• Published in: Journal of veterinary science (Suwŏn-si, Korea) Vol. 7; no. 4; pp. 343 - 348
• Main Authors: Park, K.S. (Seoul National University, Seoul, Republic of Korea), Lee, Y.S. (Seoul National University, Seoul, Republic of Korea), E-mail: leeys@snu.ac.kr, Kang, K.S. (Seoul National University, Seoul, Republic of Korea), E-mail: kangpub@snu.ac.kr
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한수의학회 01.12.2006; The Korean Society of Veterinary Science
• Subjects: Acid Phosphatase - metabolism; Bone and Bones - cytology; Cell Differentiation - physiology; Cell Separation - methods; differentiation; Fetal Blood - cytology; GENERO HUMANO; GENRE HUMAIN; Humans; Immunohistochemistry; Immunophenotyping; Infant, Newborn; MANKIND; mesenchymal cell; Mesenchymal Stem Cells - cytology; Microscopy, Phase-Contrast; Neurons - cytology; Original; Periodic Acid-Schiff Reaction; stem cell; umbilical cord blood; 수의학
• ISSN: 1229-845X; 1976-555X
• DOI: 10.4142/jvs.2006.7.4.343

Mesenchymal stem cells (MSCs) have the capabilities for self-renewal and differentiation into cells with the phenotypes of bone, cartilage, neurons and fat cells. These features of MSCs have attracted the attention of investigators for using MSCs for cell-based therapies to treat several human diseases. Because bone marrow-derived cells, which are a main source of MSCs, are not always acceptable due to a significant drop in their cell number and proliferative/differentiation capacity with age, human umbilical cord blood (UCB) cells are good substitutes for BMCs due to the immaturity of newborn cells.