Acute fatty liver of pregnancy:Over six months follow-up study of twenty-five patients

• Published in: World journal of gastroenterology : WJG Vol. 21; no. 6; pp. 1927 - 1931
• Main Authors: Xiong, Hao-Feng, Liu, Jing-Yuan, Guo, Li-Min, Li, Xing-Wang
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 14.02.2015
• Subjects: Acute; Acute Kidney Injury - diagnosis; Acute Kidney Injury - etiology; Acute Kidney Injury - physiopathology; Acute Kidney Injury - therapy; Adult; Biomarkers - blood; China; Disease Progression; failure; fatty; Fatty Liver - blood; Fatty Liver - diagnosis; Fatty Liver - etiology; Fatty Liver - therapy; Female; Follow-Up Studies; Humans; Kidney Function Tests; liver; Liver Failure, Acute - diagnosis; Liver Failure, Acute - etiology; Liver Failure, Acute - physiopathology; Liver Failure, Acute - therapy; Liver Function Tests; Predictive Value of Tests; Pregnancy; Pregnancy Complications - blood; Pregnancy Complications - diagnosis; Pregnancy Complications - etiology; Pregnancy Complications - therapy; pregnancy;Acute; Prognosis; Prospective Studies; Prospective Study; Recovery of Function; Time Factors; Young Adult; China; Acute fatty liver of pregnancy; Follow-up study; Acute liver failure; Acute renal failure
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v21.i6.1927

AIM:To evaluate the prognosis of patients with acute fatty liver of pregnancy(AFLP)6 mo or longer after discharge.METHODS:The records of pregnant patients diagnosed with AFLP at Beijing Ditan Hospital over a 16-year period were reviewed in November 2012.Patients weremonitored using abdominal ultrasound,liver and kidney functions,and routine blood examination.RESULTS:A total of 42 patients were diagnosed with AFLP during the study period,and 25 were followed.The mean follow-up duration was 54.5 mo(range:6.5-181 mo).All patients were in good physical condition,but one patient had gestational diabetes.The renal and liver functions normalized in all patients after recovery,including in those with pre-existing liver or kidney failure.The ultrasound findings were normal in12 patients,an increasingly coarsened echo-pattern and increased echogenicity of the liver in 10 patients,and mild to moderate fatty liver infiltration in 3 patients.Cirrhosis or liver nodules were not observed in any patient.CONCLUSION:Acute liver failure and acute renal failure in AFLP patients is reversible.Patients do not require any specific long-term follow-up after recovery from AFLP if their liver function tests have normalized and they remain well.